∙ Phase I and Phase II - solid tumors cohorts

• Adult (male or female) aged ≥18 years.

• Signed informed consent prior to any study-specific procedures.

• Patients who are willing to make themselves available for the duration of the study and are willing to follow study procedures.

• Have a performance status on the Eastern Cooperative Oncology Group (ECOG) scale of:

• Phase I - 0 or 1; Phase II - 0-2.

• Have an estimated life expectancy of ≥12 weeks.

• Have adequate organ function including:

• a. Hematologic:

⁃ ANC ≥1.5 x 109/L

⁃ Platelets ≥100 x 109/L

⁃ Hemoglobin ≥90 g/L b. Hepatic:

⁃ Albumin ≥30 g/L

⁃ Bilirubin ≤1.5 times upper limit of normal (ULN)

⁃ ALT and AST ≤2.5 x ULN. If the liver has tumor involvement, AST and ALT ≤5 x ULN are acceptable.

‣ c. Renal:

⁃ Estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 d. Blood coagulation:

⁃ International Normalized Ratio (INR) or activated partial prothrombin time (aPTT) \<1.5 x ULN and \> 0.8 x LLN lower limit of normal (LLN).

• Have discontinued all chemotherapy, investigational therapy, molecularly targeted therapy, and cancer-related hormonal therapy at least 30 days prior to study enrollment (6 weeks for mitomycin-C or nitrosoureas).

• Have discontinued biologic therapy and immunotherapy at least 21 days prior to study enrollment.

• Patients who have had radiation therapy must be fully recovered in the opinion of the investigator prior to enrolling on study.

⁃ Are recovered or recovering from the acute adverse effects of any chemotherapy, biologic therapy, immunotherapy, molecularly-targeted therapy, cancer-related hormonal therapy, and investigational therapy (≤Grade 1 or baseline), with the exception of alopecia or Grade 2 neuropathy.

⁃ Have received at least 1 but no more than 4 prior systemic therapies for CLL.

⁃ Patients who have had surgery must be fully recovered in the opinion of the investigator prior to enrolling on study (but not less than 28 days for major surgery and 14 days for minor surgery).

⁃ Female patients with reproductive potential must agree to use 2 forms of highly effective contraception during the study and for at least 3 months following the last dose of IMP. Sexually active male patients must use a barrier method of contraception (condom) during the study and for at least 3 months following the last dose of IMP.

⁃ Females with child-bearing potential must have had a negative pregnancy test result ≤28 days prior to the first dose of IMP, as well as ≤1 day prior to the first dose of IMP.

⁃ Patients must be, in the judgment of the investigator, appropriate candidates for experimental therapy, and no standard therapy would confer clinical benefit to the patients.

⁃ Patients must have at least one lesion that is measurable by RECIST v.1.1.

∙ Phase I 17. Patients must have histologically proven evidence of any type of metastatic solid tumor (excluding primary brain tumor) that is evaluable and for whom no approved therapy with demonstrated clinical benefit is available or patients who are intolerant or have declined standard therapy.

∙ Phase II 18. Patients must have histologically proven evidence of a solid tumor that is locally advanced and/or metastatic and for whom no approved therapy with demonstrated clinical benefit is available or patients who are intolerant or have declined standard therapy as follows:

• Cutaneous melanoma

• Prostate cancer

• Pancreatic cancer

∙ Phase II - CLL cohort

• Adult (male or female) aged ≥18 years.

• Signed informed consent prior to any study-specific procedures.

• Patients who are willing to make themselves available for the duration of the study and are willing to follow study procedures.

• Subjects with confirmed diagnosis of per iwCLL 2008.

• Documented disease progression that meets at least one of the iwCLL criteria for requiring treatment.

• Measurable disease defined by either absolute lymphocyte count (ALC ≥ 5 x 109/L) or nodal lesion by computed tomography (CT).

• Have a performance status on the Eastern Cooperative Oncology Group (ECOG) scale ≤ 2.

• Have an estimated life expectancy of ≥16 weeks.

• Have adequate organ function including:

• a. Adequate hematologic function in the absence of transfusions (within 6 weeks prior to first dose of study medication) and independent of growth factor support for at least 7 days with the exception of pegylated G-CSF which requires at least 14 days, defined as:

⁃ WBC ≥3.0 x 109/L

⁃ ANC ≥1.0 x 109/L

⁃ Platelets ≥50 x 109/L or ≥ 25 × 109/L if thrombocytopenia is related to CLL b. Hepatic:

⁃ Albumin ≥30 g/L

⁃ Bilirubin ≤2 x ULN. Subjects with known Gilbert's Syndrome or disease-related hemolysis must have a total bilirubin ≤ 3 x ULN

⁃ ALT and AST ≤2.5 x ULN. c. Renal:

⁃ Estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 d. Blood coagulation:

⁃ International Normalized Ratio (INR) or activated partial prothrombin time (aPTT) \<1.5 x ULN and \> 0.8 x LLN.

⁃ Have discontinued all chemotherapy, immunotherapy, investigational therapy, biologic therapy, molecularly targeted therapy, and cancer-related hormonal therapy at least 30 days prior to study enrollment (6 weeks for mitomycin-C or nitrosoureas).

⁃ Are recovered or recovering from the acute adverse effects of any chemotherapy, biologic therapy, immunotherapy, molecularly targeted therapy, cancer-related hormonal therapy, and investigational therapy (≤Grade 1 or baseline), with the exception of alopecia or Grade 2 neuropathy.

⁃ The subject must also agree to pretreatment and on-treatment bone marrow aspirates.

⁃ Have received at least 1, but not more than 3 prior lines of therapy according to current guidelines.

⁃ Patients who have had surgery must be fully recovered in the opinion of the investigator prior to enrolling on study (but not less than 28 days for major surgery and 14 days for minor surgery).

⁃ Female patients with reproductive potential must agree to use 2 forms of highly effective contraception during the study and for at least 3 months following the last dose of IMP. Sexually active male patients must use a barrier method of contraception (condom) during the study and for at least 3 months following the last dose of IMP.

⁃ Females with child-bearing potential must have had a negative pregnancy test result ≤28 days prior to the first dose of IMP, as well as ≤1 day prior to the first dose of IMP.

⁃ Patients must be, in the judgment of the investigator, appropriate candidates for experimental therapy, and no standard therapy would confer clinical benefit to the patients.